Metastatic prostate cancer hijacks DNA program for embryonic development
20 Jul 2020 17:00
Metastatic prostate cancer cells that spread throughout the patient's body reactivate a DNA program responsible for fetal prostatic development, new research shows. Cancer researchers led by Wilbert Zwart of the Netherlands Cancer Institute and Oncode Institute, and Matthew Freedman of the Harvard Dana-Farber Cancer Institute in Boston, demonstrated this process in tissue samples taken from hundreds of surgically removed prostate tumors.
This reactivation of an embryonic DNA program during metastasis has never before been documented in cancer research.
The researchers have published their findings on July 20, 2020, in the scientific journal Nature Genetics. Yanyun Zhu, PhD researcher at the Netherlands Cancer Institute, is one of the leading researchers.
MM Pomerantz et al., Prostate cancer resurrects developmental epigenomic programs during metastatic progression, Nature Genetics 20 July 2020. DOI: 10.1038/s41588-020-0664-8.
Microscopic image of prostate cancer that has spread to a patient's lymph node.